Psychedelic substances such as psilocybin, LSD, MDMA, ketamine, and peyote are currently being investigated for their potential to treat mental health conditions such as depression, anxiety, PTSD, and addiction. While the mechanisms behind how these substances work in the brain are not yet fully understood, studies suggest that they may enhance neural plasticity and disrupt normal patterns of brain activity, which can help break down neurological loops that trap people in destructive patterns of thinking. Here’s what you need to know about the latest findings:

Full Doses vs. Microdosing

Studies have shown that full doses of psychedelic drugs can be effective in relieving the symptoms of major depressive disorder. However, microdosing, the practice of taking small amounts of psychedelic substances, has also gained popularity as a potential treatment for depression (1). A 2019 study found that microdosers reported improvements in mental health and mood, including reduced stress, improved emotional stability, and attenuation of symptoms of depression, anxiety, post-traumatic stress, and obsessive-compulsive disorder (2). Another study conducted in 2021 found that adults who microdose psychedelics report health-related motivations and lower levels of anxiety and depression compared to non-microdosers (5).

The Potential Benefits

The potential benefits of psychedelic substances for mental health are significant. Many people who have tried full doses or microdosing report improvements in mood, creativity, concentration, productivity, and ability to empathize with others (6). These anecdotal reports are supported by lab studies of psilocybin and LSD microdoses, which tend to show improvements in mental health and well-being (1). Psychedelic substances may also offer a more sustainable and accessible treatment option for mental health conditions than traditional antidepressants, which can have significant side effects and may not work for everyone (5).

The Risks

It’s important to note that there are still risks associated with the use of psychedelic substances, even in small doses. While microdosing is generally considered safe, it can still cause side effects such as anxiety, paranoia, and altered perceptions (2). It’s also important to use these substances under the guidance of a qualified medical professional who can monitor your response and ensure your safety.


The use of psychedelic substances for mental health is an exciting area of research, and the results of the studies conducted so far are promising. While there are still risks associated with the use of these substances, the potential benefits are significant, and may offer a new treatment option for those who are struggling with mental health conditions. If you’re interested in exploring the use of psychedelic substances for your own well-being check out our webpage and unlock your full potential.

  2. Fjournal.pone.0211023

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